If you are a Visual Studio developer, I'm sure you might have got this error atleast onece in your life. And I would call this as the "Most frustrating issue that can happen to any developer"
Because, you need to troubleshoot this may be for few days just to get a single breakpoint enabled.
As far as I know there is no clear cut solution for this issue. So, first try the following:
First Clean the solution ( Build > Clean Solution)
If it does not work, delete Bin and Obj folders and Build
Still no luck? Restart the Visual Stidio IDE
If non of these options work for you, go to
Debug > Windows > Modules. It will show you the path which the symbols are loaded. You can check the
symbol status there.